Cellular imaging with confocal fluorescence laser microscopy gave rise to many new insights into the cellular machinery. One interesting observation suggests that morphology of cell nucleus plays a key role for neutrophilic function, which is an essential part of the innate immune system of most mammals.
Due to the increasing availability of high resolution 3D images coming from the microscope, machine learning becomes a promising tool for automatically discovering underlying hidden structures. Here, the major difficulty consists of selecting an appropriate representation for characterizing the morphology of cell nucleus.
In this work we tackle this problem and propose a fully unsupervised mechanism for finding structure in high-throughput 3D image data. The key component of our approach is based on Generic Fourier Transform (GFT) for 2D images, which for 3D involves spherical coordinate transformation prior to fast Discrete Fourier Transformation.
On top on GFT we apply dimensionality reduction with Principal Component Analysis, followed by generative cluster analysis with a Gaussian Mixture Model. We validate our new approach first on a synthetic 3D-MNIST dataset with random rotations, where quantitative and qualitative results confirm the applicability of the proposed pipeline for exploring shape space in a purely unsupervised manner.
1 KB DNA LADDER, 500UL PER KIT |
M-DNA-1KB |
CORNING |
1/pk |
EUR 70 |
Description: Bioscience Mol Bio; DNA Ladder |
COVER GLASS, NO. 1, SQUARE 18 X 18MM |
2845-18 |
CORNING |
100/pk |
EUR 112 |
Description: Cover Glass; Cover Glass, CGW |
COVER GLASS, NO. 2, SQUARE 18 X 18MM |
2855-18 |
CORNING |
50/pk |
EUR 83 |
Description: Cover Glass; Cover Glass, CGW |
COVER GLASS, NO. 1 1/2, SQUARE 18 X 18MM |
2850-18 |
CORNING |
100/pk |
EUR 131 |
Description: Cover Glass; Cover Glass, CGW |
FT4 (Free thyroxine) ELISA test |
18 |
Biobase |
96T/Box |
Ask for price |
|
Description: ELISA based test for quantitative detection of FT4 (Free thyroxine) |
Encephalitozoon cuniculi whole cell antigen suspension |
18-2002 |
Medicago |
1 ml |
EUR 365 |
Anti-Trimethyl-Histone H3 (Lys27) Rabbit Monoclonal Antibody, Clone#RM175 |
M06819-18 |
BosterBio |
100ug |
EUR 479 |
Description: Anti-Trimethyl-Histone H3 (Lys27) Rabbit Monoclonal Antibody, Clone#RM175 tested in WB, ELISA, Multiplex, IHC, reactive to All Vertebrates |
IL-7, Interleukin-7, human |
RC212-18 |
Bio Basic |
2ug |
EUR 104.38 |
|
TSLP, Thymic Stromal Lymphopoietin, human |
RC213-18 |
Bio Basic |
2ug |
EUR 104.38 |
|
LIF, Leukemia inhibitory factor, human |
RC214-18 |
Bio Basic |
2ug |
EUR 101.33 |
|
FGF-7, KGF-1, Fibroblast Growth Factor-7, human |
RC215-18 |
Bio Basic |
2ug |
EUR 104.38 |
|
Epiregulin, human |
RC216-18 |
Bio Basic |
5ug |
EUR 104.38 |
|
IFN lambda 1 (IL-29), human |
RC217-18 |
Bio Basic |
5ug |
EUR 104.38 |
|
GMF beta, Glia Maturation Factor beta, human |
RC218-18 |
Bio Basic |
2ug |
EUR 104.38 |
|
BMP-7, Bone Morphogenetic Protein-7, human |
RC219-18 |
Bio Basic |
2ug |
EUR 104.38 |
|
IL-7, Interleukin-7, murine (mouse) |
RC232-18 |
Bio Basic |
2ug |
EUR 104.38 |
|
LIF, Leukemia inhibitory factor, murine (mouse) |
RC234-18 |
Bio Basic |
5ug |
EUR 104.38 |
|
FGF-7, Fibroblast Growth Factor-7, murine (mouse) |
RC235-18 |
Bio Basic |
2ug |
EUR 104.38 |
|
GMF beta, Glia Maturation Factor beta, murine (mouse) |
RC238-18 |
Bio Basic |
2ug |
EUR 104.38 |
|
IL-7, Interleukin-7, rat |
RC252-18 |
Bio Basic |
2ug |
EUR 104.38 |
|
VEGF165, rat |
RC256-18 |
Bio Basic |
1mg |
EUR 2364.2 |
|
GMF beta, rat |
RC258-18 |
Bio Basic |
2ug |
EUR 101.33 |
|
IFN-tau, Interferon-tau, ovine |
RC277-18 |
Bio Basic |
2ug |
EUR 104.38 |
|
NAP-2, CXCL7, human |
RC312-18 |
Bio Basic |
2ug |
EUR 104.38 |
|
MCP-3, CCL7, human |
RC315-18 |
Bio Basic |
2ug |
EUR 104.38 |
|
MCP-3, CCL7, murine (mouse) |
RC335-18 |
Bio Basic |
2ug |
EUR 104.38 |
|
NAP-2, CXCL7, rat |
RC352-18 |
Bio Basic |
2ug |
EUR 104.38 |
|
MCP-3, CCL7, rat |
RC355-18 |
Bio Basic |
2ug |
EUR 104.38 |
|
UBC7, Ubiquitin Conjugating Enzyme 7 (His6-tagged), human |
RC612-18 |
Bio Basic |
50ug |
EUR 169.63 |
|
Sparc, human |
RC712-18 |
Bio Basic |
50ug |
EUR 152.66 |
|
AlbuSorbâ„¢ Kit |
A185-18 |
Biotech Support Group |
18 grams AlbuSorb™ Bead & Buffer (360 preps, 25 µl serum) |
Ask for price |
Description: Albumin Removal Kit |
Syntaxin 18 (Syntaxin 18) Antibody |
20-abx115967 |
Abbexa |
|
|
|
Syntaxin 18 (Syntaxin 18) Antibody |
abx238449-100ug |
Abbexa |
100 ug |
EUR 509 |
|
Interleukin 18 (IL-18) Antibody |
20-abx225240 |
Abbexa |
-
EUR 370.00
-
EUR 606.00
-
EUR 314.00
|
|
|
Cytokeratin 18 / CK-18 (KRT18) Antibody |
abx413457-5ml |
Abbexa |
5 ml |
EUR 606 |
|
Cytokeratin 18 / CK-18 (KRT18) Antibody |
abx413458-1ml |
Abbexa |
1 ml |
EUR 342 |
|
Mouse Interleukin-18 (IL-18) Antibody |
30119-05111 |
AssayPro |
150 ug |
EUR 261 |
Human Interleukin-18 (IL-18) Antibody |
32199-05111 |
AssayPro |
150 ug |
EUR 261 |
18-Hydroxycamptothecin |
TBZ1416 |
ChemNorm |
unit |
Ask for price |
AG-18 |
A1173-100 |
ApexBio |
100 mg |
EUR 490 |
Description: AG18 is an inhibitor of EGFR kinase with IC50 values of 35?M. [3]AG18 acts as general tyrosine kinase inhibitor to block tyrosine phosphorylation and events downstream of tyrosine phosphorylation. |
AG-18 |
A1173-25 |
ApexBio |
25 mg |
EUR 189 |
Description: AG18 is an inhibitor of EGFR kinase with IC50 values of 35?M. [3]AG18 acts as general tyrosine kinase inhibitor to block tyrosine phosphorylation and events downstream of tyrosine phosphorylation. |
AG-18 |
A1173-5 |
ApexBio |
5 mg |
EUR 108 |
Description: AG18 is an inhibitor of EGFR kinase with IC50 values of 35?M. [3]AG18 acts as general tyrosine kinase inhibitor to block tyrosine phosphorylation and events downstream of tyrosine phosphorylation. |
AG-18 |
A1173-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 113 |
Description: AG18 is an inhibitor of EGFR kinase with IC50 values of 35?M. [3]AG18 acts as general tyrosine kinase inhibitor to block tyrosine phosphorylation and events downstream of tyrosine phosphorylation. |
AP 18 |
B7349-10 |
ApexBio |
10 mg |
EUR 144 |
Description: AP-18 is a selective channel blocker which can reversibly inhibit TRPA1 of human and mouse with IC50 of 3.1 µM and 4.5 µM, respectively. |
AP 18 |
B7349-25 |
ApexBio |
25 mg |
EUR 270 |
Description: AP-18 is a selective channel blocker which can reversibly inhibit TRPA1 of human and mouse with IC50 of 3.1 µM and 4.5 µM, respectively. |
AP 18 |
B7349-5 |
ApexBio |
5 mg |
EUR 112 |
Description: AP-18 is a selective channel blocker which can reversibly inhibit TRPA1 of human and mouse with IC50 of 3.1 µM and 4.5 µM, respectively. |
AP 18 |
B7349-50 |
ApexBio |
50 mg |
EUR 425 |
Description: AP-18 is a selective channel blocker which can reversibly inhibit TRPA1 of human and mouse with IC50 of 3.1 µM and 4.5 µM, respectively. |
PPM-18 |
C4074-10 |
ApexBio |
10 mg |
EUR 192 |
Description: PPM-18 is a chemically synthesized naphthoquinone derivative and an anti-inflammatory agent that inhibits the expression of inducible NO synthase (iNOS). NOS catalyzes the oxidation of the amino acid L-arginine to form NO. |
PPM-18 |
C4074-25 |
ApexBio |
25 mg |
EUR 363 |
Description: PPM-18 is a chemically synthesized naphthoquinone derivative and an anti-inflammatory agent that inhibits the expression of inducible NO synthase (iNOS). NOS catalyzes the oxidation of the amino acid L-arginine to form NO. |
PPM-18 |
C4074-5 |
ApexBio |
5 mg |
EUR 129 |
Description: PPM-18 is a chemically synthesized naphthoquinone derivative and an anti-inflammatory agent that inhibits the expression of inducible NO synthase (iNOS). NOS catalyzes the oxidation of the amino acid L-arginine to form NO. |
Chicken Interleukin 18,IL-18 ELISA KIT |
CN-00786C1 |
ChemNorm |
96T |
EUR 434 |
Chicken Interleukin 18,IL-18 ELISA KIT |
CN-00786C2 |
ChemNorm |
48T |
EUR 284 |
Canine Interleukin 18,IL-18 ELISA KIT |
CN-00930C1 |
ChemNorm |
96T |
EUR 465 |
Canine Interleukin 18,IL-18 ELISA KIT |
CN-00930C2 |
ChemNorm |
48T |
EUR 315 |
PoFAine Interleukin 18,IL-18 ELISA Kit |
CN-01257P1 |
ChemNorm |
96T |
EUR 458 |
PoFAine Interleukin 18,IL-18 ELISA Kit |
CN-01257P2 |
ChemNorm |
48T |
EUR 307 |
Rat Interleukin 18,IL-18 Elisa Kit |
CN-01601R1 |
ChemNorm |
96T |
EUR 455 |
Rat Interleukin 18,IL-18 Elisa Kit |
CN-01601R2 |
ChemNorm |
48T |
EUR 304 |
Mouse Interleukin 18,IL-18 ELISA Kit |
CN-02452M1 |
ChemNorm |
96T |
EUR 447 |
Mouse Interleukin 18,IL-18 ELISA Kit |
CN-02452M2 |
ChemNorm |
48T |
EUR 296 |
Human Interleukin 18,IL-18 ELISA KIT |
CN-03294H1 |
ChemNorm |
96T |
EUR 434 |
Human Interleukin 18,IL-18 ELISA KIT |
CN-03294H2 |
ChemNorm |
48T |
EUR 284 |
Human cytokeratin 18,CK-18 ELISA Kit |
CN-04602H1 |
ChemNorm |
96T |
EUR 464 |
Human cytokeratin 18,CK-18 ELISA Kit |
CN-04602H2 |
ChemNorm |
48T |
EUR 313 |
Human cytokein 18,CK 18 ELISA kit |
E01C2328-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Human cytokein 18,CK 18 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human cytokein 18,CK 18 ELISA kit |
E01C2328-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Human cytokein 18,CK 18 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human cytokein 18,CK 18 ELISA kit |
E01C2328-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Human cytokein 18,CK 18 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat cytokein 18,CK 18 ELISA kit |
E02C2328-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Rat cytokein 18,CK 18 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat cytokein 18,CK 18 ELISA kit |
E02C2328-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Rat cytokein 18,CK 18 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat cytokein 18,CK 18 ELISA kit |
E02C2328-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Rat cytokein 18,CK 18 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse cytokein 18,CK 18 ELISA kit |
E03C2328-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Mouse cytokein 18,CK 18 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse cytokein 18,CK 18 ELISA kit |
E03C2328-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Mouse cytokein 18,CK 18 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse cytokein 18,CK 18 ELISA kit |
E03C2328-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Mouse cytokein 18,CK 18 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit cytokein 18,CK 18 ELISA kit |
E04C2328-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit cytokein 18,CK 18 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit cytokein 18,CK 18 ELISA kit |
E04C2328-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit cytokein 18,CK 18 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit cytokein 18,CK 18 ELISA kit |
E04C2328-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit cytokein 18,CK 18 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Interleukin 18, IL-18 ELISA Kit |
CSB-E04609m-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
|
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin 18, IL-18 in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Mouse Interleukin 18, IL-18 ELISA Kit |
1-CSB-E04609m |
Cusabio |
-
EUR 804.00
-
EUR 5099.00
-
EUR 2704.00
|
-
1 plate of 96 wells
-
10 plates of 96 wells each
-
5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin 18, IL-18 in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Rat Interleukin 18, IL-18 Elisa Kit |
CSB-E04610r-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
|
Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 18, IL-18 in samples from serum, plasma, cell culture supernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Rat Interleukin 18, IL-18 Elisa Kit |
1-CSB-E04610r |
Cusabio |
-
EUR 603.00
-
EUR 4247.00
-
EUR 2260.00
|
-
1 plate of 96 wells
-
10 plates of 96 wells each
-
5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 18, IL-18 in samples from serum, plasma, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Monkey cytokein 18,CK 18 ELISA kit |
E09C2328-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A competitive ELISA for quantitative measurement of Monkey cytokein 18,CK 18 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey cytokein 18,CK 18 ELISA kit |
E09C2328-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A competitive ELISA for quantitative measurement of Monkey cytokein 18,CK 18 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey cytokein 18,CK 18 ELISA kit |
E09C2328-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A competitive ELISA for quantitative measurement of Monkey cytokein 18,CK 18 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human cytokeratin 18, CK-18 ELISA Kit |
CSB-E09172h-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
|
Description: Quantitativesandwich ELISA kit for measuring Human cytokeratin 18, CK-18 in samples from serum, plasma, tissue homogenates, cell lysates, cell
culturesupernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human cytokeratin 18, CK-18 ELISA Kit |
1-CSB-E09172h |
Cusabio |
-
EUR 900.00
-
EUR 5476.00
-
EUR 2900.00
|
-
1 plate of 96 wells
-
10 plates of 96 wells each
-
5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Human cytokeratin 18, CK-18 in samples from serum, plasma, tissue homogenates, cell lysates, cell
culturesupernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Dog Interleukin 18, IL-18 ELISA KIT |
CSB-E09848c-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
|
Description: Quantitativesandwich ELISA kit for measuring Dog Interleukin 18, IL-18 in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Then we apply our proposed technique to a new collected dataset of high resolution 3D images of neutrophile nuclei suggesting a clustering model with six significant clusters of morphological cell nuclei prototypes. We visualize differences in the cell shape clusters by providing prototypical examples of neutrophilic cell nuclei.