Bridging-induced microphase separation: photobleaching experiments, chromatin domains and the need for active reactions.

We review the mechanism and consequences of the ‘bridging-induced attraction’, a generic biophysical principle that underpins some existing models for chromosome organization in 3D.

This attraction, which was revealed in polymer physics-inspired computer simulations, is a generic clustering tendency arising in multivalent chromatin-binding proteins, and it provides an explanation for the biogenesis of nuclear bodies and transcription factories via microphase separation.

Palladium Standard, 100UL

C016-100UL 100UL
EUR 123

Glutathione Standard, 100UL

C018-100UL 100UL
EUR 122

Histone H3 Polyclonal Antibody, Rabbit, 100UL

A004-100UL 100UL
EUR 263

MonoMe Lys4 Histone H3 Polyclonal, Rabbit, 100UL

A005-100UL 100UL
EUR 263

DiMe Lys4 Histone H3 Polyclonal, Rabbit, 100UL

A006-100UL 100UL
EUR 263

TriMe Lys4 Histone H3 Polyclonal, Rabbit, 100UL

A007-100UL 100UL
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Neptune 100ul barrier tip

BT100 10 trays of 96 / pack
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100UL ZYMARK TIPS, RACKED

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10-100UL SINGLE CHANNEL PIPETTOR

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100UL UNIVERSAL FIT FILTER TIPS

TF-100 1000/pk
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100UL "MAXYMUM RECOVERY" FILTER TIPS

TF-100-L 1000/pk
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Amikacin Sulfate USP (1:2)

A003-1G 1 g
EUR 92

Amikacin Sulfate USP (1:2)

A003-5G 5 g
EUR 239

6-TAMRA, SE in DMSO:100uL

90097 100uL
EUR 307
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6-Rox, SE in DMSO:(100uL)

90098 100uL
EUR 307
Description: Minimum order quantity: 1 unit of 100uL

100UL MAXYMUM RECOVERY ZYMARK TIPS, RACKED

ZT-100-L-R 960/pk
EUR 245
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100UL ZYMARK TIPS, RACKED & PRE-STERILIZED

ZT-100-R-S 960/pk
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10-100ul Filter Tip, Natural, 1000/Pack

FT224 1PK, 1000UNIT
EUR 79.58
  • Product category: Labware/Pipette Tips - Filter Tips/10-100ul

100UL ZYMARK FILTER TIPS, RACKED & PRE-STERILIZED

ZTF-100-R-S 960/pk
EUR 433
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AXYPET 10-100UL SINGLE CHANNEL PIPETTOR ISO17025 3X4

AP-100-ALT 1/pk
EUR 199
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

AXYPET 10-100UL SINGLE CHANNEL PIPETTOR ISO17025 3X10

AP-100-STD 1/pk
EUR 203
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

10-100ul Filter Tip, Natural, Sterile, 96/Rack

FT224-RNS 1PK, 96UNIT
EUR 53.92
  • Product category: Labware/Pipette Tips - Filter Tips/10-100ul

100UL "MAXYMUM RECOVERY" FILTER TIPS, RACKED, PRE-STERILIZED

TF-100-L-R-S 960/pk
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Description: Filter Tip; Maximum Recovery Filter Tips - Axygen

100UL UNIVERSAL FIT FILTER TIPS, RACKED & PRE-STERILIZED

TF-100-R-S 960/pk
EUR 258
Description: Filter Tip; Filter Tips Pipette - Axygen

LAMBDA PLUS SINGLE CHANNEL PIPETTOR,10 TO 100UL,AUTOCLAVABLE

4073 1/pk
EUR 182
Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Single Channel Pipettors

100UL MAXYMUM RECOVERY ZYMARK FILTER TIPS, RACKED & PRE-STERILIZED

ZTF-100-L-R-S 960/pk
EUR 478
Description: Robotic Tips; Max Rec Robotic Filter Tips - Axygen

10-100ul Filter Tip, Natural, Sterile, 96/Rack x 10

FT224-RNSB 1PK, 960UNIT
EUR 98.74
  • Product category: Labware/Pipette Tips - Filter Tips/10-100ul

100UL CLEAR PIPET TIPS FOR "OASIS" AUTOMATED LIQUID HANDLING SYSTEM

OT-100-R 960/pk
EUR 362
Description: Robotic Tips; Robotic tips - Axygen

LAMBDA PLUS SINGLE CHANNEL PIPETTOR,10 TO 100UL,AUTOCLAVABLE ISO17025 3X4

4073-ALT 1/pk
EUR 199
Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Multi-Channel Pipettors

LAMBDA PLUS SINGLE CHANNEL PIPETTOR,10 TO 100UL,AUTOCLAVABLE ISO17025 3X10

4073-STD 1/pk
EUR 203
Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Single Channel Pipettors

100UL AXYGEN MULTIRACK FILTERED TIP, RACKED, STERILE, 960/PCK 5 PCK/CASE

MRF-100-R-S 960/pk
EUR 327
Description: Filter Tip; MultiRack Filter tips

100UL CLEAR PIPET TIPS FOR TECAN EVO/ CALIPER ZEPHYR AUTOMATED LIQUID HANDLING SYSTEM

EV-100-R 960/pk
EUR 348
Description: Robotic Tips; Robotic tips - Axygen

TIPS, 100UL NAT GRAD LOW BIND BARRIER IN HINGED RACKS,S,BK,960/3840

4137 960/pk
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Description: Filter Tip; Deckwork Filter Tips

100UL AXYGEN MULTIRACK FILTERED TIP, RACKED, STERILE, MAXYMUM RECOVERY, 960/PCK 5 PCK/CASE

MRF-100-L-R-S 960/pk
EUR 357
Description: Filter Tip; MultiRack Maxymum Recovery Filter tips

100UL CLEAR PRE-STERILIZED FILTERED PIPET TIPS FOR TECAN EVO/ CALIPER ZEPHYR AUTOMATED LIQUID HANDLING SYSTEM

EVF-100-R-S 960/pk
EUR 403
Description: Robotic Tips; Filter Tips Robotic Tips - Axygen

Phospho-ABL1-Y245 Rabbit pAb

AP0001-100ul 100 ul
EUR 384

Phospho-Histone H3-S10 Rabbit mAb

AP0002-100ul 100 ul
EUR 459

Phospho-ABL1-Y204 Rabbit pAb

AP0003-100ul 100 ul
EUR 384

Phospho-AKT-T450 Rabbit pAb

AP0004-100ul 100 ul
EUR 384

Phospho-AKT2-S474 Rabbit pAb

AP0005-100ul 100 ul
EUR 384

Phospho-APP-T668 Rabbit pAb

AP0006-100ul 100 ul
EUR 384

Phospho-FAS-Y291 Rabbit pAb

AP0007-100ul 100 ul
EUR 384

Phospho-ATM-S1981 Rabbit pAb

AP0008-100ul 100 ul
EUR 384

Phospho-Bad-S155 Rabbit pAb

AP0009-100ul 100 ul
EUR 384

Phospho-Bad-S112 Rabbit pAb

AP0010-100ul 100 ul
EUR 384

Phospho-Bad-S136 Rabbit pAb

AP0011-100ul 100 ul
EUR 384

Phospho-BRAF-S445 Rabbit pAb

AP0012-100ul 100 ul
EUR 384

Phospho-CCNE1-T395 Rabbit pAb

AP0013-100ul 100 ul
EUR 384

Phospho-CDK1-T14 Rabbit pAb

AP0015-100ul 100 ul
EUR 384

Phospho-CDK1-Y15 Rabbit pAb

AP0016-100ul 100 ul
EUR 384

Phospho-CHEK1-S280 Rabbit pAb

AP0017-100ul 100 ul
EUR 384

Phospho-CHEK1-S317 Rabbit pAb

AP0018-100ul 100 ul
EUR 384

Phospho-CREB1-S133 Rabbit pAb

AP0019-100ul 100 ul
EUR 384

Phospho-ATF2-T71 Rabbit pAb

AP0020-100ul 100 ul
EUR 384

Phospho-Dnmt1-pS714 Rabbit pAb

AP0021-100ul 100 ul
EUR 384

Phospho-Dnmt1-pY399 Rabbit pAb

AP0022-100ul 100 ul
EUR 384

Phospho-EGFR-Y845 Rabbit pAb

AP0023-100ul 100 ul
EUR 384

Phospho-EGFR-Y998 Rabbit pAb

AP0024-100ul 100 ul
EUR 384

Phospho-EGFR-T669 Rabbit pAb

AP0025-100ul 100 ul
EUR 384

Phospho-EGFR-Y992 Rabbit pAb

AP0026-100ul 100 ul
EUR 384

Phospho-EGFR-Y1068 Rabbit mAb

AP0027-100ul 100 ul
EUR 459

Phospho-EGFR-Y1148 Rabbit pAb

AP0028-100ul 100 ul
EUR 384

Phospho-EIF4EBP1-T37/46 Rabbit pAb

AP0030-100ul 100 ul
EUR 384

Phospho-EIF4EBP1-T70 Rabbit pAb

AP0031-100ul 100 ul
EUR 384

Phospho-EIF4EBP1-S65 Rabbit pAb

AP0032-100ul 100 ul
EUR 384

Phospho-ELK1-S383 Rabbit pAb

AP0033-100ul 100 ul
EUR 384

Phospho-ERBB4-Y1284 Rabbit pAb

AP0034-100ul 100 ul
EUR 384

Phospho-FGFR1-Y766 Rabbit pAb

AP0035-100ul 100 ul
EUR 384

Phospho-FGFR1-Y653 Rabbit pAb

AP0036-100ul 100 ul
EUR 384

Phospho-FGFR1-Y654 Rabbit pAb

AP0037-100ul 100 ul
EUR 384

Phospho-c-Fos-T232 Rabbit pAb

AP0038-100ul 100 ul
EUR 384

Phospho-GSK3B-S9 Rabbit pAb

AP0039-100ul 100 ul
EUR 384

Phospho-HSPB1-S15 Rabbit pAb

AP0040-100ul 100 ul
EUR 384

Phospho-HSPB1-S82 Rabbit pAb

AP0041-100ul 100 ul
EUR 384

Phospho-INSR-Y1361 Rabbit pAb

AP0042-100ul 100 ul
EUR 384

Phospho-INSR-Y1146 + IGF1R-Y1131 Rabbit pAb

AP0043-100ul 100 ul
EUR 384

Phospho-INSR-Y1150/IGF1R-Y1135 Rabbit pAb

AP0044-100ul 100 ul
EUR 384

Phospho-INSR-Y1151/IGF1R-Y1136 Rabbit pAb

AP0045-100ul 100 ul
EUR 384

Phospho-INSR-Y1345 Rabbit pAb

AP0046-100ul 100 ul
EUR 384

Phospho-c-Jun-S73 Rabbit pAb

AP0047-100ul 100 ul
EUR 384

Phospho-c-Jun-S63 Rabbit pAb

AP0048-100ul 100 ul
EUR 384

Phospho-Jun-T239 Rabbit pAb

AP0049-100ul 100 ul
EUR 384

Phospho-Jun-S243 Rabbit pAb

AP0050-100ul 100 ul
EUR 384

Phospho-ERK3-S189 Rabbit pAb

AP0051-100ul 100 ul
EUR 384

Phospho-Tau-T231 Rabbit mAb

AP0053-100ul 100 ul
EUR 459

Phospho-STAT1-Y701 Rabbit mAb

AP0054-100ul 100 ul
EUR 459

Phospho-p38 MAPK-Y322 Rabbit pAb

AP0055-100ul 100 ul
EUR 384

Phospho-p38 MAPK-T180 Rabbit pAb

AP0056-100ul 100 ul
EUR 384

Phospho-MAPK14-Y182 Rabbit pAb

AP0057-100ul 100 ul
EUR 384

Phospho-MAP3K5-S1033 Rabbit pAb

AP0058-100ul 100 ul
EUR 384

Phospho-MAP3K5-S83 Rabbit pAb

AP0059-100ul 100 ul
EUR 384

Phospho-MAP3K5-T918 Rabbit pAb

AP0061-100ul 100 ul
EUR 384

Phospho-MAP2K1-S217 Rabbit pAb

AP0062-100ul 100 ul
EUR 384

Phospho-MAP2K1-S298 Rabbit pAb

AP0063-100ul 100 ul
EUR 384

Phospho-MAP2K1-pS221 Rabbit pAb

AP0064-100ul 100 ul
EUR 384

Phospho-MAP2K1-T286 Rabbit pAb

AP0065-100ul 100 ul
EUR 384

Phospho-MAP2K3-S189/MAP2K6-S207 Rabbit pAb

AP0066-100ul 100 ul
EUR 384

Phospho-MAP2K4-S80 Rabbit pAb

AP0067-100ul 100 ul
EUR 384

Phospho-MAP2K4-S257 Rabbit pAb

AP0068-100ul 100 ul
EUR 384

Phospho-MAP2K4-T261 Rabbit pAb

AP0069-100ul 100 ul
EUR 384

Phospho-Stat3-Y705 Rabbit pAb

AP0070-100ul 100 ul
EUR 384

Phospho-MAP3K7-S412 Rabbit pAb

AP0071-100ul 100 ul
EUR 384

Phospho-MAX-S11 Rabbit pAb

AP0072-100ul 100 ul
EUR 384

Phospho-MDM2-S166 Rabbit pAb

AP0073-100ul 100 ul
EUR 384

Phospho-MDM2-S260 Rabbit pAb

AP0074-100ul 100 ul
EUR 384

Phospho-MEF2C-S396 Rabbit pAb

AP0075-100ul 100 ul
EUR 384

Phospho-MET-Y1003 Rabbit pAb

AP0076-100ul 100 ul
EUR 384

Phospho-MET-Y1349 Rabbit pAb

AP0077-100ul 100 ul
EUR 384

Phospho-MET-Y1234 Rabbit pAb

AP0078-100ul 100 ul
EUR 384

Phospho-MET-Y1235 Rabbit pAb

AP0079-100ul 100 ul
EUR 384

Phospho-MYC-T58 Rabbit pAb

AP0080-100ul 100 ul
EUR 384

Phospho-MAP2K6-S207/MAP2K3-S189 Rabbit pAb

AP0081-100ul 100 ul
EUR 384

Phospho-MYC-S62 Rabbit pAb

AP0082-100ul 100 ul
EUR 384

Phospho-p53-S15 Rabbit pAb

AP0083-100ul 100 ul
EUR 384

Phospho-p53-S9 Rabbit pAb

AP0085-100ul 100 ul
EUR 384

Phospho-RAC1-S71 Rabbit pAb

AP0086-100ul 100 ul
EUR 384

Phospho-RAF1-S621 Rabbit pAb

AP0087-100ul 100 ul
EUR 384

Phospho-RB-S795 Rabbit pAb

AP0088-100ul 100 ul
EUR 384

Phospho-Rb-S811 Rabbit pAb

AP0089-100ul 100 ul
EUR 384

Phospho-SMC1A-S957 Rabbit pAb

AP0090-100ul 100 ul
EUR 384

Phospho-Histone H3-T11 Rabbit pAb

AP0093-100ul 100 ul
EUR 384

Phospho-mTOR-S2448 Rabbit pAb

AP0094-100ul 100 ul
EUR 384

Phospho-Histone H3-S28 Rabbit pAb

AP0097-100ul 100 ul
EUR 384

Phospho-AKT-S473 Rabbit pAb

AP0098-100ul 100 ul
EUR 384

Phospho-γH2A.X-S139 Rabbit pAb

AP0099-100ul 100 ul
EUR 384

Phospho-Btk-Y223 Rabbit pAb

AP0100-100ul 100 ul
EUR 384

Phospho-c-Jun-S63 Rabbit mAb

AP0105-100ul 100 ul
EUR 459

Phospho-STAT1-S727 Rabbit pAb

AP0109-100ul 100 ul
EUR 384

Phospho-mTOR-S2448 Rabbit mAb

AP0115-100ul 100 ul
EUR 459

Phospho-PRKAA1-T183/PRKAA2-T172 Rabbit pAb

AP0116-100ul 100 ul
EUR 384

Phospho-Rb-S780 Rabbit mAb

AP0117-100ul 100 ul
EUR 459

Phospho-c-JUN-S73 Rabbit pAb

AP0119-100ul 100 ul
EUR 384

Phospho-GSK3A-S21 Rabbit pAb

AP0120-100ul 100 ul
EUR 384

Phospho-MAP2K2-T394 Rabbit pAb

AP0121-100ul 100 ul
EUR 384

Phospho-NF-kB p65-T254 Rabbit pAb

AP0122-100ul 100 ul
EUR 384

Phospho-NF-kB p65-S276 Rabbit pAb

AP0123-100ul 100 ul
EUR 384

Phospho-NF-kB p65-S536 Rabbit pAb

AP0124-100ul 100 ul
EUR 384

Phospho-NFKB1-S337 Rabbit pAb

AP0125-100ul 100 ul
EUR 384

Phospho-c-JUN-S243 Rabbit pAb

AP0126-100ul 100 ul
EUR 384

Phospho-ATF2-S62/S44 Rabbit pAb

AP0127-100ul 100 ul
EUR 384

Phospho-ATF2-T69/T51 Rabbit pAb

AP0128-100ul 100 ul
EUR 384

Phospho-ATF2-T71/T53 Rabbit pAb

AP0129-100ul 100 ul
EUR 384

Phospho-ATF2-S112/S94 Rabbit pAb

AP0130-100ul 100 ul
EUR 384

Phospho-c-Myc-T58 Rabbit pAb

AP0131-100ul 100 ul
EUR 384

Phospho-c-Myc-S373 Rabbit pAb

AP0132-100ul 100 ul
EUR 384

Phospho-ELK1-S389 Rabbit pAb

AP0133-100ul 100 ul
EUR 384

Phospho-GATA1-S142 Rabbit pAb

AP0134-100ul 100 ul
EUR 384

Phospho-STAT1-Y701 Rabbit pAb

AP0135-100ul 100 ul
EUR 384

Phospho-STAT4-Y693 Rabbit pAb

AP0137-100ul 100 ul
EUR 384

Phospho-STAT5A-Y694 Rabbit pAb

AP0138-100ul 100 ul
EUR 384

Phospho-STAT5A-S780 Rabbit pAb

AP0139-100ul 100 ul
EUR 384

Phospho-AKT-S473 Rabbit pAb

AP0140-100ul 100 ul
EUR 384

Phospho-PTEN-S380/T382/T383 Rabbit pAb

AP0141-100ul 100 ul
EUR 384

Phospho-FAK-Y861 Rabbit pAb

AP0142-100ul 100 ul
EUR 384

Phospho-Bad-S112 Rabbit pAb

AP0143-100ul 100 ul
EUR 384

Phospho-Bad-S136 Rabbit pAb

AP0144-100ul 100 ul
EUR 384

Phospho-Estrogen Receptor alpha-S104 Rabbit pAb

AP0145-100ul 100 ul
EUR 384

Phospho-Estrogen Receptor alpha-S118 Rabbit pAb

AP0146-100ul 100 ul
EUR 384

Phospho-PGR-S190 Rabbit pAb

AP0147-100ul 100 ul
EUR 384

Phospho-HER2/ErbB2-Y877 Rabbit pAb

AP0148-100ul 100 ul
EUR 384

Phospho-HER2/ErbB2-Y1221/Y1222 Rabbit pAb

AP0149-100ul 100 ul
EUR 384

Phospho-MYOD1-S200 Rabbit pAb

AP0150-100ul 100 ul
EUR 384

Phospho-PRKD1-S738 Rabbit pAb

AP0151-100ul 100 ul
EUR 384

Phospho-HER2/ERBB2-Y1248 Rabbit pAb

AP0152-100ul 100 ul
EUR 384

Phospho-EGFR-S1070 Rabbit pAb

AP0153-100ul 100 ul
EUR 384

Phospho-EGFR-Y1092 Rabbit pAb

AP0154-100ul 100 ul
EUR 384

Phospho-PXN-Y118 Rabbit pAb

AP0156-100ul 100 ul
EUR 384

Phospho-p53-S6 Rabbit pAb

AP0157-100ul 100 ul
EUR 384

Phospho-p53-S15 Rabbit pAb

AP0158-100ul 100 ul
EUR 384

Phospho-PRKD1-S910 Rabbit pAb

AP0159-100ul 100 ul
EUR 384

Phospho-p53-S46 Rabbit pAb

AP0161-100ul 100 ul
EUR 384

Phospho-Tau-S356 Rabbit pAb

AP0162-100ul 100 ul
EUR 384

Phospho-Tau-S396 Rabbit pAb

AP0163-100ul 100 ul
EUR 384

Phospho-PLCG1-Y783 Rabbit pAb

AP0164-100ul 100 ul
EUR 384

Phospho-GRIN1-S896 Rabbit pAb

AP0165-100ul 100 ul
EUR 384

Phospho-P90RSK-T348 Rabbit pAb

AP0166-100ul 100 ul
EUR 384

Phospho-Tau-S235 Rabbit pAb

AP0167-100ul 100 ul
EUR 384

Phospho-Tau-T205 Rabbit pAb

AP0168-100ul 100 ul
EUR 384

Phospho-Tau-S214 Rabbit pAb

AP0169-100ul 100 ul
EUR 384

Phospho-Tau-S404 Rabbit pAb

AP0170-100ul 100 ul
EUR 384

Including post-translational modification reactions involving these multivalent proteins can account for the fast dynamics of the ensuing clusters, as is observed via microscopy and photobleaching experiments. The clusters found in simulations also give rise to chromatin domains that conform well with the observation of A/B compartments in HiC experiments.