Bridging-induced microphase separation: photobleaching experiments, chromatin domains and the need for active reactions.

We review the mechanism and consequences of the ‘bridging-induced attraction’, a generic biophysical principle that underpins some existing models for chromosome organization in 3D.

This attraction, which was revealed in polymer physics-inspired computer simulations, is a generic clustering tendency arising in multivalent chromatin-binding proteins, and it provides an explanation for the biogenesis of nuclear bodies and transcription factories via microphase separation.

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LAMBDA PLUS SINGLE CHANNEL PIPETTOR,10 TO 100UL,AUTOCLAVABLE ISO17025 3X4

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LAMBDA PLUS SINGLE CHANNEL PIPETTOR,10 TO 100UL,AUTOCLAVABLE ISO17025 3X10

4073-STD 1/pk
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Description: Corning and Axygen Liquid Handling Equipment; Corning Lambda Plus Single Channel Pipettors

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Description: Filter Tip; MultiRack Maxymum Recovery Filter tips

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Acetyl-Histone H3-K9/K14/K18/K23/K27 pAb

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30229-100ul 100ul
EUR 252

m6A Polyclonal Antibody

30230-100ul 100ul
EUR 252

NANOS3 Polyclonal Antibody

30231-100ul 100ul
EUR 252

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EUR 252

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30233-100ul 100ul
EUR 252

SRCAP Polyclonal Antibody

30234-100ul 100ul
EUR 252

MON1A Polyclonal Antibody

30235-100ul 100ul
EUR 252

Ubiquityl-Histone H2B-Lys120 Polyclonal Antibody

30236-100ul 100ul
EUR 252

NNAT Polyclonal Antibody

30237-100ul 100ul
EUR 252

DHX9 Polyclonal Antibody

30238-100ul 100ul
EUR 252

PSBA Polyclonal Antibody

30239-100ul 100ul
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PEBP4 Polyclonal Antibody

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MT-ND4 Polyclonal Antibody

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POU1F1 Polyclonal Antibody

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EUR 252

ZDHHC4 Polyclonal Antibody

30244-100ul 100ul
EUR 252

IRF2BP2 Polyclonal Antibody

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C10orf67 Polyclonal Antibody

30246-100ul 100ul
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LAPTM5 Polyclonal Antibody

30247-100ul 100ul
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[KO Validated] BAK1 Polyclonal Antibody

30248-100ul 100ul
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[KO Validated] DDX58 Polyclonal Antibody

30249-100ul 100ul
EUR 252

[KO Validated] EDN1 Polyclonal Antibody

30250-100ul 100ul
EUR 252

[KO Validated] MSH6 Polyclonal Antibody

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EUR 252

[KO Validated] IRF9 Polyclonal Antibody

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EUR 252

ACP1 Polyclonal Antibody

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[KO Validated] AKR1A1 Polyclonal Antibody

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[KO Validated] HSP90AB1 Polyclonal Antibody

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[KO Validated] EMD Polyclonal Antibody

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EUR 252

[KO Validated] TDP2 Polyclonal Antibody

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[KO Validated] CAT Polyclonal Antibody

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[KO Validated] SHH Polyclonal Antibody

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[KO Validated] PRDX3 Polyclonal Antibody

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[KO Validated] IDH1 Polyclonal Antibody

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[KO Validated] TRIM21 Polyclonal Antibody

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[KO Validated] ADA Polyclonal Antibody

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[KO Validated] EMD Polyclonal Antibody

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[KO Validated] AKR1B1 Polyclonal Antibody

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[KO Validated] BSG Polyclonal Antibody

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[KO Validated] CA2 Polyclonal Antibody

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[KO Validated] PSIP1 Polyclonal Antibody

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EUR 252

[KO Validated] CTTN Polyclonal Antibody

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[KO Validated] LGALS1 Polyclonal Antibody

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[KO Validated] CTNND1 Polyclonal Antibody

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[KO Validated] FADD Polyclonal Antibody

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EUR 252

CYP24A1 Polyclonal Antibody

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EUR 252

[KO Validated] LIG4 Polyclonal Antibody

30276-100ul 100ul
EUR 252

[KO Validated] FTL Polyclonal Antibody

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EUR 252

[KO Validated] PTBP1 Polyclonal Antibody

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[KO Validated] BUB1 Polyclonal Antibody

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[KO Validated] NLRX1 Polyclonal Antibody

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[KO Validated] MPG Polyclonal Antibody

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[KO Validated] CBR1 Polyclonal Antibody

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[KO Validated] UBE2C Polyclonal Antibody

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[KO Validated] FADD Polyclonal Antibody

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EUR 252

[KO Validated] TFRC Polyclonal Antibody

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EUR 252

[KO Validated] PTBP1 Polyclonal Antibody

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EUR 252

[KO Validated] COMT Polyclonal Antibody

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[KO Validated] ATG4D Polyclonal Antibody

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EUR 252

[KO Validated] ALDH9A1 Polyclonal Antibody

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EUR 252

[KO Validated] STK4 Polyclonal Antibody

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EUR 252

[KO Validated] PSIP1 Polyclonal Antibody

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K6-linkageSpecificPolyubiquitin Polyclonal Antibody

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SALL1 Polyclonal Antibody

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MEK1/MEK2 Polyclonal Antibody

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EUR 252

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EUR 252

RXRB Polyclonal Antibody

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EUR 252

FBXW8 Polyclonal Antibody

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EUR 252

SMG5 Polyclonal Antibody

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EUR 252

HIS-O2 Polyclonal Antibody

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PFK Polyclonal Antibody

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EUR 252

PTPRO Polyclonal Antibody

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EUR 252

CEACAM5 Monoclonal Antibody

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EUR 252

TUBB3 Monoclonal Antibody

30323-100ul 100ul
EUR 252

ANGPTL8 Polyclonal Antibody

30324-100ul 100ul
EUR 252

PML(isoform 5) Polyclonal Antibody

30325-100ul 100ul
EUR 252

E-Cadherin Monoclonal Antibody

30326-100ul 100ul
EUR 252

STOX1 Polyclonal Antibody

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EUR 252

LYST Polyclonal Antibody

30328-100ul 100ul
EUR 252

TBCCD1 Polyclonal Antibody

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ED1 Polyclonal Antibody

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EUR 252

OSBPL5 Polyclonal Antibody

30331-100ul 100ul
EUR 252

CYSLTR1 Polyclonal Antibody

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EUR 252

NUPR1 Polyclonal Antibody

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EUR 252

SHFM1 Polyclonal Antibody

30334-100ul 100ul
EUR 252

AJUBA Polyclonal Antibody

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Including post-translational modification reactions involving these multivalent proteins can account for the fast dynamics of the ensuing clusters, as is observed via microscopy and photobleaching experiments. The clusters found in simulations also give rise to chromatin domains that conform well with the observation of A/B compartments in HiC experiments.